The rs2294918 E434K variant modulates patatin-like phospholipase domain-containing 3 expression and liver damage
نویسندگان
چکیده
منابع مشابه
a meta-analysis of the association between the i148m variant of patatin-like phospholipase domain containing 3 gene and the presence of chronic hepatitis c
conclusions the current meta-analysis showed an association between frequency of gg genotype of pnpla3 and the risk of development of chc in various populations throughout the world. results five hospital-based case-control studies were included in the final analysis. the overall frequency of pnpla3 gene polymorphisms was 20.4% (205/1005) in chc and 10.23% (53/518) in controls. the summary odds...
متن کاملcorrelation between patatin-like phospholipase domain-containing protein 3 gene polymorphisms and liver cirrhosis in a chinese han population with chronic hepatitis b
results the allele and genotype distributions of pnpla3 rs738409 and rs2281135 were not significantly different between the chb and lc groups. after segregation on the basis of sex, no significant correlation between pnpla3 (rs738409 and rs2281135) genotypes/alleles and liver cirrhosis was detected. moreover, none of the haplotypes in pnpla3 (rs738409 and rs2281135) was found to be statisticall...
متن کاملDissociation Between Fatty Liver and Insulin Resistance in Humans Carrying a Variant of the Patatin-Like Phospholipase 3 Gene
OBJECTIVE In a genome-wide association scan, the rs738409 C>G single nucleotide polymorphism (SNP) in the patatin-like phospholipase 3 gene (PNPLA3) was strongly associated with increased liver fat but not with insulin resistance estimated from fasting values. We investigated whether the SNP determines liver fat independently of visceral adiposity and whether it may even play a role in protecti...
متن کاملA Meta-Analysis of the Association Between the I148M Variant of Patatin-Like Phospholipase Domain Containing 3 Gene and the Presence of Chronic Hepatitis C.
CONTEXT The objective of the current study was to evaluate the association between the I148M variant of patatin-like phospholipase domain-containing protein 3 (PNPLA3) and the presence of Chronic Hepatitis C (CHC) across different populations. EVIDENCE ACQUISITION This study was a meta-analysis of all relevant researches published in the literature from year 2000 to 2015. The odds ratios (ORs...
متن کاملRole of Patatin-Like Phospholipase Domain-Containing 3 on Lipid-Induced Hepatic Steatosis and Insulin Resistance in Rats
UNLABELLED Genome-wide array studies have associated the patatin-like phospholipase domain-containing 3 (PNPLA3) gene polymorphisms with hepatic steatosis. However, it is unclear whether PNPLA3 functions as a lipase or a lipogenic enzyme and whether PNPLA3 is involved in the pathogenesis of hepatic insulin resistance. To address these questions we treated high-fat-fed rats with specific antisen...
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ژورنال
عنوان ژورنال: Hepatology
سال: 2016
ISSN: 0270-9139
DOI: 10.1002/hep.28370